Regional MVD and central VF damage in advanced glaucoma eyes

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It has been found that in advanced glaucoma, the sensitivity of the 10 degree central visual field (VF) is significantly correlated with both the density of superficial vessels in the macula and the thickness of the ganglion cell complex (GCC) . In eyes with advanced open-angle glaucoma, researchers sought to determine if there was a correlation between macular vessel density (MVD) as measured by optical coherence tomography (OCTA) angiography and field sensitivity. visuals (VF) at 10-2. Analysis of macular OCTA of 44 patients and sensitivity to 10-2 VF was performed [mean deviation (MD) <−10 dB]. The average sensitivity (MS) of VFs at regional and global levels was determined using total deviation graphs. Using 2 sector definitions, 3x3mm OCTA scans2 and 6×6mm2 were used to acquire superficial and deep MVD, respectively. MVD measurements and macular GCC thickness were acquired simultaneously from the same scan using spectral domain optical coherence tomography. For this purpose, we used linear regression models for the analysis (R2). Comparing the 2 maps, the 1 with the lowest MS had less MVD and GCC on the surface in every region, regardless of scan size. Individual image sectors showed weaker associations than the early diabetic retinopathy treatment study map. The MVD in the deep layers was found to be unrelated to the central MS. GCC correlations were stronger than MVD associations in the central MS at 5 degrees, although 66 mm2 and perifoveolar vascular density showed better associations with central 10-degree MS than did GCC thickness (eg, R2 25.7 to 48.1 µm and 7.8% to 32.5%, respectively).MVD and GCC complement measurements in eyes with advanced glaucoma due to the central MVD-VF relationship at 10 degrees more strongest relative to GCC and the strongest GCC-central relationship at 5 degree VF association compared to MVD. A longitudinal study is essential to compare the value of GCC and MVD over time.

Source: journals.lww.com/glaucomajournal/Fulltext/2022/09000/The_Association_Between_Regional_Macula_Vessel.6.aspx

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